Selective Biofilm Inhibition through Mucin-Inspired Engineering of Silk Glycopolymers|Werlang, C. A., Sahoo, J. K., Cárcarmo-Oyarce G., Stevens, C., Uzun, C., Putnik, R., Hasturk, O., Choi, J., Kaplan, D. J., Ribbeck, R.
Journal of American Chemical Society (2024).
Mucins protect against Streptococcus pneumoniae virulence by suppressing pneumolysin expression | Bath, J., Bjånes, E., Goekeri, C., Hsiao, J., Uzun, D., Nouailles, G., Nizet, V., Ribbeck K.
Journal of Clinical Investigation (2024).
Prevotella are major contributors of sialidases in the human vaginal microbiome|Pelayo, P., Hussain, F. A., Werlang, C. A., Wu, C. M., Woolston, B. M., Xiang, C. M., Rutte, L., France, M. T., Ravel, J., Ribbeck, K., Kwon, D. S., Balskus, E.P.
PNAS (2024).
Mucus‐Inspired Self‐Healing Hydrogels: A Protective Barrier for Cells against Viral Infection|Bej, R., Stevens, C. A., Nie, C., Ludwig, K., Degen, G. D., Kerkhoff, Y., Pigaleva, M., Adler, J. M., Bustos, N. A., Page, T. M., Trimpert, J., Block, S., Kaufer, B. B., Ribbeck, K., Haag, R.
Advanced Materials (2024).
Theme issue: In vitro mucus models|Kramer, J., Ribbeck K.
Advanced drug delivery reviews, 115053 (2023).
The role of mucosal barriers in disease progression and transmission|
Bustos, N. A., Ribbeck, K., Wagner, C. E.
Advanced Drug Delivery Reviews 200, 115008 (2023)
Mucin glycans drive oral microbial community composition and function|Wu, C. M., Smith-Dupont, K. B., Bustos, N. A., Krupkin, M., Wagner, C. E., Witten, J., Ribbeck, K., Tiemeyer, M., Griffen, A. L., Ribbeck, K.
Nature Partner Journals (npj) Biofilms and Microbiomes (2023).
Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels| Wagner, C. E., Krupkin, M.; Smith-Dupont, K. B., Wu, C. M., Bustos, N. A.; Witten, J., Ribbeck, K.
Biomacromolecules (2023).
Host-derived O-glycans inhibit toxigenic conversion by a virulence-encoding phage in Vibrio cholerae | Wang B. X., Takagi J., McShane A., Park J. H., Aoki K., Griffin C., Teschler J., Tiemeyer M., Hevey R., Yildiz F., Ribbeck K.
The EMBO Journal, e111562 (2022).
News & Views Spotlight: https://www.embopress.org/doi/full/10.15252/embj.2022113204
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity | Takagi J., Aoki K., Turner B.S., Lamont S., Lehoux S., Kavanaugh N., Gulati M., Valle Arevalo A., Lawrence T.J., Kim C.Y., Bakshi B., Ishihara M., Nobile C.J., Cummings R.D., Wozniak D.J., Tiemeyer M., Hevey R., Ribbeck K.
Nature Chemical Biology, 1-12 (2022).
Role of MUC5B during Group B Streptococcal Vaginal Colonization | Burcham L., Bath J., Werlang C., Lyon L., Liu N., Evans C., Ribbeck K., Cummings R.D., Wozniak D.J., Tiemeyer M., Hevey R., Ribbeck K., Doran K.J.
Mbio 13 (2), e0039-22 (2022).
Spatial configuration of charge and hydrophobicity tune particle transport through mucus | Samad T., Witten J., Grodzinsky AJ., Ribbeck K.
Biophysical Journal 121 (2), 277-287 (2022).
Mucus| McShane A., Bath J., Jaramillo A., Ridley C., Walsh A., Evans C., Thornton D., Ribbeck K.
Current Biology, 31:R938-R945 (2021).
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain| Hahn G., Wu C., Lee S., Lutz S., Khurana S., Baden L., Haneuse S., Qiao D., Hecker J., DeMeo D., Tanzi R., Choudhary M., Etemad B., Mohammadi A., Esmaeilzadeh E., Cho M., Li J., Randolph A., Laird N., Weiss S., Silverman E., Ribbeck K., Lange C.
Genetic Epidemiology, 1-9 (2021).
Stereochemical Control Yields Mucin Mimetic Polymers| Kruger A., Brucks S., Yan T., Cárcamo-Oyarce G., Wei Y., Wen D., Carvalho D., Hore M., Ribbeck K., Schrock R., Kiessling L.
American Chemical Society Central Science, 7:624-630 (2021)
Two-component signaling systems regulate diverse virulence-associated traits in Pseudomonas aeruginosa| Wang B., Cady K., Cárcamo-Oyarce G., Ribbeck K., Laub M.
Applied and Environmental Microbiology, 87:e03089-20 (2021)
Mucin glycans suppress quorum sensing pathways and genetic transformation in Streptococcus mutans | Werlang C., Chen W., Aoki K., Wheeler K., Tymm C., Mileti C., Burgos A., Kim K., Tiemeyer M., Ribbeck K.
Nature Microbiology,6:574–583 (2021)
ClpP1P2 peptidase activity promotes biofilm formation in P. aeruginosa | Mawla G., Hall B., Cárcamo-Oyarce G., Grant R., Zhang J., Kardon J., Ribbeck K., Sauer R., Baker T.
Molecular Microbiology, 115:1094–1109 (2021)
Mucin glycans signal through the sensor kinase RetS to inhibit virulence-associated traits in Pseudomonas aeruginosa | Wang B., Wheeler K., Cady K., Lehoux S., Cummings R., Laub M., Ribbeck K.
Current Biology, 31:1-13 (2020)
Home, sweet home: how mucus accommodates our microbiota | Wang B., Wu C., Ribbeck K.
FEBS, febs.15504 (2020)
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection | Wheeler K., Cárcamo-Oyarce G., Turner B., Dellos-Nolan S., Co, J., Lehoux S., Cummings R., Wozniak D., Ribbeck K.
Nature Microbiology, 4:2146-2154 (2019)
Molecular characterization of mucus binding | Witten J., Samad T., Ribbeck K.
ACS Biomacromolecules, 4:1505-1513 (2019)
Mucus and mucin environments reduce the efficacy of polymyxin and fluoroquinolone antibiotics | Samad T., Co, J., Witten J., Ribbeck K.
ACS Biomaterials Science & Engineering, 5:1189-1194 (2019)
Engineering mucus to study and influence the microbiome | Werlang C., Cárcamo-Oyarce G., Ribbeck K.
Nature Review Materials, 4:134–145 (2019)
Enhanced diffusion by binding to the crosslinks of a polymer gel | Goodrich C., Brenner M., Ribbeck K.
Nature Communications, 9:4348 (2018)
Mucins trigger dispersal of Pseudomonas aeruginosa biofilms | Co J., Cárcamo-Oyarce G., Billings N., Wheeler K., Grindy S., Holten-Andersen N., Ribbeck K.
Nature Partner Journals Biofilms and Microbiomes, 4:23 (2018)
Mucins and their role in shaping the functions of mucus barriers | Wagner C.E., Wheeler K.M, Ribbeck K.
Annual Review of Cell and Developmental Biology, 34:189-215 (2018)
Selective permeability of mucus barriers | Witten J., Samad T., Ribbeck K.
Current Opinion in Biotechnology, 52:124-133 (2018)
A rheological study of the of the association and dynamics of MUC5AC gels | Wagner C.E., Turner B.S, Rubinstein M., McKinley G. H., Ribbeck K.
Biomacromolecules, 18(11):3654-3664 (2017)
Loss of the mucosal barrier alters the progenitor cell niche via Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling | Zhang L., Turner B., Ribbeck K, Ten Hagen KG.
Journal of Biological Chemistry, 292:2131 (2017)
Charge influences substrate recognition and self-assembly of hydrophobic FG sequences | Chen W.G, Witten J., Grindy S.C., Holten-Andersen N., Ribbeck K.
Biophysical Journal, 113(9), 2088-2099 (2017)
The particle in the spider’s web: transport through biological hydrogels | Witten J., Ribbeck K.
Nanoscale, 9(24):8080-8095 (2017)
Probing the potential of mucus permeability to signify preterm birth risk | Smith-Dupont K., Wagner C., Witten J., Conroy K., Rudoltz H., Pagidas K., Snegovskikh V., House M., and Ribbeck K.
Scientific Reports, 7(1), 10302 (2017)
Swimming bacteria promote dispersal of non-motile staphylococcal species | Samad T., Billings N, Birjiniuk A., Crouzier T., Doyle P.S., Ribbeck K.
The ISME Journal, 11(8):1933-1937 (2017)
Salivary mucins promote the coexistence of competing oral bacterial species | Frenkel E.S., Ribbeck K.
The ISME Journal, 11(5):1286-1290 (2017)
Antiviral Agents from Multivalent Presentation of Sialyl Oligosaccharides on Brush Polymers | Tang S., Puryear W. B., Seifried B. M., Dong X., Runstadler J. A., Ribbeck K., Olsen B. D.
ACS Macro Letters, 5 (3), 413-418 (2016)
Salivary mucins in host defense and disease prevention | Frenkel E.S., Ribbeck K.
Journal of Oral Microbiology, 7: 29759 (2015)
Modulating mucin hydration and lubrication by deglycosylation and polyethylene glycol binding | Crouzier T., Boettcher K., Geonnotti A., Kavanaugh N., Hirsch J.B., Ribbeck K., Lieleg O.
Advanced Materials Interfaces, 2:1500308 (2015)
Probing the Role of Mucin-Bound Glycans in Bacterial Repulsion by Mucin Coatings | Co J., Crouzier T., Ribbeck K.
Advanced Materials Interfaces, 2:1500179 (2015)
Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport | Kim M., Chen W.G., Kang J.W., Glassman M.J., Ribbeck K., Olsen B.D.
Advanced Materials, 27(28): 4207-4212 (2015)
Tuning the properties of mucin via layer-by-layer assembly | Ahn J., Crouzier T., Ribbeck K., Rubner M.F., Cohen R.E.
Biomacromolecules, 16(1): 228-235 (2015)
Material properties of biofilms: a review of methods for understanding permeability and mechanics | Billings N., Birjiniuk A, Samad T., Doyle P., Ribbeck K.
Reports on Progress in Physics: 78(3), 036601 (2015)
Salivary mucins protect surfaces from colonization by cariogenic bacteria | Frenkel E.S., Ribbeck K.
Applied and Environmental Microbiology: 81(1), 332-338 (2014)
Zebrafish as a Model to Study Live Mucus Physiology | Jetov I., Samuelesson T., Yao G., Amsterdam A., Ribbeck K.
Scientific Reports 4, Article Number: 6653 (2014)
Mucins Supress Virulence Traits of Candida albicans | Kavanaugh N.L., Zhang A.Q., Nobile C.J., Johnson, A.D., Ribbeck, K.
mBio, 5(5):e01911-14 (2014)
Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers | Polak R, Crouzier T, Lim RM, Ribbeck K, Beppu MM, Pitombo RN, Cohen RE, Rubner MF
Biomacromolecules, 15(8):3093-8 (2014)
Single Particle Tracking Reveals Spatial and Dynamic Organization of the E. coli Biofilm Matrix | Birjiniuk, A., Billings, N., Nance, E., Hanes, J., Ribbeck, K., and Doyle, P.S
New Journal of Physics,16() 085014 (2014)
Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier | Li L., Crouzier T., Sarkar A., Dunphy L., Han J., Ribbeck K.
Biophysical Journal, 105(6): 1357-1365 (2013)
Cell patterning with mucin biopolymers | Crouzier T., Jang H., Ahn J., Stocker R., Ribbeck K.
Biomacromolecules,14(9): 3010-3016 (2013)
Cervical Mucus Properties Stratify Risk for Preterm Birth | Critchfield A.S., Yao G., Jaishankar A., Friedlander R.S., Lieleg O., Doyle P.S., McKinley G., House M. and Ribbeck K.
PLOS ONE, 8(8):e69528 (2013)
The extracellular matrix component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms | Billings N., Millan M.R., Caldara M., Rusconi R., Tarasova Y., Stocker R., Ribbeck K.
PLOS Pathogens, 9(8):e1003526 (2013)
Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state | Caldara M., Friedlander R.S., Kavanaugh N., Aizenberg J., Foster K., Ribbeck K.
Current Biology, 22(24): 2325-2330 (2012)
Mucin multilayers assembled through sugar-lectin interactions | Crouzier T, Beckwitt CH, Ribbeck K.
Biomacromolecules, 13(10):3401-8 (2012)
Microfluidic in vitro system for the quantitative study of the stomach mucus barrier | Li, L.D., Lieleg, O., Jang, S.K., Ribbeck, K., Han, J.
Lab Chip, 12(20):4071-9 (2012)
Mucin biopolymers as broad-spectrum antiviral agents | Lieleg, O., Lieleg, C., Bloom, J., Buck, C.B., Ribbeck, K.
Biomacromolecules, 13(6): 1724-1732 (2012)
Selected antimicrobial essential oils eradicate Psuedomonas spp. and Staphylococcus aureus biofilms | Kavanaugh, N.K., Ribbeck, K.
Applied and Environmental Microbiology, 78(11): 4057-4061 (2012)
An absorption chromatography assay to probe bulk particle transport through hydrogels | Vladescu, I., Lieleg, O., Jang, S., and Ribbeck, K.
Journal of Pharmaceutical Sciences, 101(1): 436-42 (2012)
Biological hydrogels as selective diffusion barriers | Lieleg O., Ribbeck K.
Trends in Cell Biology, 21(9), pp. 543-551 (2011)
Mechanical robustness of Pseudomonas aeruginosa biofilms | Lieleg O., Caldara M., Baumgaertal R., Ribbeck K.
Soft Matter, vol.7, Pages 3307-3314 (2011)
Charge as a selection criterion for translocation through nuclear pore complexes | Colwell L., Brenner M., Ribbeck K.
PLoS Computational Biology 6:e1000747 (2010)
Characterization of particle translocation through mucin hydrogels | Lieleg O., Vladescu I., and Ribbeck, K.
Biophysical Journal, 98:1782 (2010)
Do viruses use vectors to penetrate mucus barriers? | Ribbeck K.
Bioscience Hypothesis, Vol. 2, Issue 6, Pages 357-446 (2009)
Adsorption of Human Papillomavirus 16 to live human sperm. | Pérez-Andino J., Buck C.B., and Ribbeck K.
PLoS ONE 4(6):e5847 (2009)
Meiotic Spindle- Sculpted by Severing. | Ribbeck K and Mitchison TJ.
Current Biology 16(21):R923-5 (2007)
Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient. | Clausen T and Ribbeck K.
PLoS ONE 2: e244 (2007)
NuSAP can link mitotic chromatin to microtubules. | Ribbeck K, Raemaekers T, Carmeliet G, Mattaj I.
Current Biology. 17(3):230-6 (2007)
NuSAP, a mitotic RanGTP target that can stabilise and cross-link microtubules. | Ribbeck K, Santarella R, Groen A, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison T, Ellenberg J, Hoenger A and Mattaj I.
Mol Biol Cell 17, 2646-2660 (2006)
Crm1 is a mitotic effector of Ran-GTP in somatic cells. | Arnaoutov A, Azuma Y, Ribbeck K, Joseph J, Boyarchuk Y, Karpova T, McNally J, Dasso M.
Nat Cell Biol. 7(6), 626-32 (2005)
NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. | Raemaekers T, Ribbeck K, Beaudouin J, Annaert W, Van Camp M, Stockmans I, Smets N, Bouillon R, Ellenberg J, Carmeliet G.
J Cell Biol 162, 1017-29 (2003)
Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurement and computer simulation. | Görlich D, Seewald M and Ribbeck K.
EMBO J 22, 1088-110 (2003)
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. | Ribbeck K and Görlich D.
EMBO J 21, 2664-71 (2002)
Kinetic analysis of translocation through nuclear pore complexes. | Ribbeck K and Görlich D.
EMBO J 20, 1320-1330 (2001)
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. | Bachi A, Braun IC, Rodrigues JP, Pante N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Gorlich D, Carmo-Fonseca M, Izaurralde E.
RNA. 6(1), 136-58 (2000)
The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. | Ribbeck K, Kutay U., Paraskeva E. and Görlich D.\
Current Biology 9, 47-50 (1999)
Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. | Bayliss R, Ribbeck K, Akin D, Kent H. M, Feldherr C. M, Görlich D, and Stewart M.
J Mol Biol 293, 579-93 (1999)
A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. | Ferrari MB, Ribbeck K, Hagler DJ, Spitzer NC.
J Cell Biol. 15;141(6):1349-56 (1998).
NTF2 mediates nuclear import of Ran. | Ribbeck K, Lipowsky G., Kent H. M., Stewart M. & Görlich D.
EMBO J 17, 6587-6598 (1998)