Current team / Alumni
Erica Shapiro Frenkel
DDS PhD Student
The goal of my research is to understand how salivary mucins influence the physiology of oral bacteria. Specifically, I’m interested in learning how salivary mucins help prevent dental cavity formation.
My interests lie in the self-assembly and selective transport process through biological hydrogels. I use simplified peptides as a proxy for complex biological polymers to dissect the biophysical properties required for tunable mechanical and transport-related properties.
Kathryn Blakey Dupont
My research focuses on understanding the biophysical and biochemical qualities that govern selective permeability in human mucus. Using cervical mucus as a case study, I apply a microfluidic device platform to investigate the characteristics that distinguish molecules that permeate through or are hindered by the mucus barrier. My hobbies include running, knitting, baking, and hiking.
My primary interests are in mucin glycoprotein biochemistry, biophysics and molecular biology and their involvement in diseased and applications to therapeutics.
Outside interests include music; singing with various Boston choral and church groups including the Tanglewood Festival Chorus, and flute. I am an active member at the Roxbury Presbyterian Church.
I am interested in investigating transport of nanoparticles through mucus. In particular, I'm working on understanding how different particle parameters like size, shape and surface chemistry effect transport, and how this knowledge can be applied to improve drug delivery.
I am currently a senior at MIT studying Biological Engineering. When I'm not in lab studying transport through biological hydrogels and their microrheology, I enjoy being a volunteer EMT and solving puzzles.
My main interests are in understanding physical and chemical interactions with mucus for substances ranging from small molecules to nanoparticles. I am developing new assays and computational tools for analysis of these interactions.
My research interests focus on predicting the macroscopic rheological response of biological gels, mucus in particular, from microscropic properties. We do so through a combined approach of polymer modeling and rheological experimentation with solutions of both native mucins and fabricated mucin mimetics.
I am researching how the structure of multivalent polymers influences their functional properties. I am especially interested in how changing the display of binding sites on polymers like mucins alter their interactions with pathogens.
I'm interested in understanding how pathogens such as Pseudomonas aeruginosa sense and respond to host-derived sugars, such as those found on mucins. In particular, my goal is to understand how different sugars modulate different behaviors such as virulence and persistence.
I am interested in understanding how mucus influences bacterial behavior of pathogenic bacteria. I am particularly focused on studying bacterial interactions such as cell-to-cell communication and bacterial competition in mucus environment.
The goal of my research is to understand how the mucus environment influences microbial physiology and community dynamics. In particular, I am interested in how mucins modulate virulence and ultimately affect interactions among commensal and pathogenic microorganisms.
I am interested in the chemical and genetic basis behind microbial interactions with mucus.
The goal of my research is to understand the ways in which mucus alters microbial physiology and impacts microbial interactions. I am focused on investigating the oligosaccharides on mucins that are able to be sensed by microbes and the mechanism in which they effect microbial behavior and virulence.