BIOGEL Laboratory

Katharina Ribbeck

March 2017

Congratulations to Kelsey Wheeler for winning an NSF fellowship!

March 2017

Congratulations to Emiko Zumbro on winning first prize in the GSOFT poster prize competition at APS March Meeting!

January 2017

Welcome to our newest lab member, Caroline Werlang!

June 2016

Congratulations to Jacob on passing his qualifying exam!

April 2016

Congratulations to Katharina Ribbeck on receiving the Harold E. Edgerton Award!

April 2016

Congratulations to Emiko Zumbro for winning an NDSEG fellowship!

March 2016

Congratulations to Caroline Wagner for winning an NSERC fellowship and to Jacob Witten for winning an NSF fellowship!

January 2016

Welcome to our newest lab member, Caroline Wagner!

January 2016

The review "Salivary mucins in host defense and disease prevention" by Erica Shapiro Frenkel and Katharina Ribbeck has just been published in the Journal of Oral Microbiology! Congratulations to Erica and Katharina!

December 2015

Welcome to our newest lab member, Emiko Zumbro!

November 2015

The review "Salivary mucins in host defense and disease prevention" by Erica Shapiro Frenkel and Katharina Ribbeck has just been accepted to the Journal of Oral Microbiology! Congratulations to Erica and Katharina!

September 2015

Two new papers have been published in Advanced Materials Interfaces: "Probing the Role of Mucin-Bound Glycans in Bacterial Repulsion by Mucin Coatings" by Julia Co, Thomas Crouzier, and Katharina Ribbeck, and "Modulating mucin hydration and lubrication by deglycosylation and polyethylene glycol binding" by Thomas Crouzier and Oliver Lieleg. Congratulations to everyone involved!

September 2015

We received an NSF CAREER award for our lab!

May 2015

Congratulations to Dr. Julia Co and Dr. Alona Birjiniuk for their amazing thesis defenses!

March 2015

Welcome to our newest lab member, Jacob Witten!

February 2015

Congratulations to Dr. Kavanaugh for her fabulous thesis defense!!! We are very proud -- she is the first student to graduate from our lab.

January 2015

Congratulations to Katharina Ribbeck for receiving the Junior Bose Award for Excellence in Teaching.

November 2014

-Congrats to Wes for passing his oral quals!!

October 2014

-A new publication has been accepted in Reviews on Progress in Physics: Material properties of biofilms—a review of methods for understanding permeability and mechanics.
Congratulations to Nicole Billings, Alona Birjiniuk, Tahoura Samad and others!

October 2014

-A new publication has been accepted in Applied and Environmental Microbiology: Salivary mucins protect surfaces from colonization by cariogenic bacteria
Congratulations to Erica Shapiro!

October 2014

-A new publication has been accepted in mBio: Mucins Suppress Virulence Traits of Candida albicans.
Congratulations to Nicole Kavanaugh, Angela Zhang and others!

October 2014

-A new publication has been accepted in Scientific Reports: Zebrafish as a Model to Study Live Mucus Physiology
Congratulations to Irena Jetov and others!

September 2014

-Katharina was honored as one of Popular Science's Brilliant 10 of 2014!! Congratulations!!

August 2014

-A new publication has been accepted in Biomacromolecules: Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers. Congratulations to Roberta Polak, Thomas Crouzier and others!

June 2014

-A new publication has been accepted in New Journal of Physics: Single particle tracking reveals spatial and dynamic organization of the E. coli biofilm matrix
Congratulations to Alona Birjiniuk, Nicole Billings and others!

June 2014

-Congratulations to Wes who was awarded a fellowship as part of MIT's Biotechnology Training Program!

June 2014

-Congratulations to Kate who was awarded an NIH/AIDS travel grant!

June 2014

-Congratulations to Tahoura for passing quals!

April 2014

-Congratulations to Tahoura who was awarded a Graduate Research Fellowshipfrom the National Science Foundation!

March 2014

-Welcome to our newest lab members Kowa Chen and Tahoura Samad!

December 2013

-Katharina was featured in this month's MIT News Faculty Highlight. Check it out!

August 2013

- A new publication has been accepted in Biophysical Journal: Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier
Congratulations to Leon Li, Thomas Crouzier, and others!

July 2013

- New publications in Biomacromolecules, PLOS ONE, and PLOS Pathogens are in press! Please see the publications page. Congratulations to Thomas Crouzier, Nicole Billings, and Grace Yao!

January 2013

- Katharina Ribbeck received the 2013 John Kendrew Award for Excellence in Research and Science Communication.

December 2012

- Congratulations to Dr. Leon Li!!

November 2012

- We welcome our newest lab member Wesley Chen, a Biological Engineering graduate student!!

October 2012

- Find us at the 6th ASM Conference on Biofilms in Miami. From September 29th to October 4th.

October 2012

- A new publication has been accepted in Current Biology: Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state
Congratulations to all the authors and in particular to Marina Caldara, Ronn Friedlander and Nicole Kavanaugh!!

September 2012

- Congratulations to Julia who was awarded a Student Traineeship grant from the Cystic Fibrosis Foundation!!

August 2012

- Congratulations to Thomas and Collin for their latest publication in Biomacromolecules entitled Mucin multilayers assembled through sugar-lectin interactions.

July 2012

- A short film on the the wonderful world of mucus, written and directed by Andrew Rajczewski is now available. Go see A Mucus Story.

May 2012

- Congratulations to our own Grace Yao,winner of the BE-BMES Johnson & Johnson Excellence in Biomedical Engineering Research Prize!

January 2012

- Congratulations to Thomas who was awarded the Marie Curie International Outgoing Fellowships for career development (IOF)

Research Summary

The controlled exchange of molecules between biological entities (organelles, cells, or organisms) and their environment is critical for life. Biological gels appear well suited to achieve such selective exchange: A gel within the nuclear pore controls the passage of material between nucleus and cytoplasm. Mucus that lines our lungs allows us to expel ingested particles and defends the cells beneath from a variety of pathogens. The extracellular matrix in connective tissue regulates the exchange of ions and proteins with the epithelium and between fibroblasts. The extracellular matrix within biofilms forms a barrier toward, for example, antibiotics. Biological gels represent a whole class of molecular assemblies that are understudied, with many fascinating and important structure-function problems to investigate and medical/engineering applications to invent.

Our focus is on basic mechanisms by which mucus barriers exclude, or allow passage of different molecules and pathogens, and the mechanisms pathogens have evolved to penetrate mucus barriers. We hope to provide the foundation for a theoretical framework that captures general principles governing selectivity in mucus, and likely other biological hydrogels such as the extracellular matrix, and bacterial biofilms. Our work may also be the basis for the reconstitution of synthetic gels that mimic the basic selective properties of biological gels.