BIOGEL Laboratory

Katharina Ribbeck

January 2017

Welcome to our newest lab member, Caroline Werlang!

June 2016

Congratulations to Jacob on passing his qualifying exam!

April 2016

Congratulations to Katharina Ribbeck on receiving the Harold E. Edgerton Award!

April 2016

Congratulations to Emiko Zumbro for winning an NDSEG fellowship!

March 2016

Congratulations to Caroline Wagner for winning an NSERC fellowship and to Jacob Witten for winning an NSF fellowship!

January 2016

Welcome to our newest lab member, Caroline Wagner!

January 2016

The review "Salivary mucins in host defense and disease prevention" by Erica Shapiro Frenkel and Katharina Ribbeck has just been published in the Journal of Oral Microbiology! Congratulations to Erica and Katharina!

December 2015

Welcome to our newest lab member, Emiko Zumbro!

November 2015

The review "Salivary mucins in host defense and disease prevention" by Erica Shapiro Frenkel and Katharina Ribbeck has just been accepted to the Journal of Oral Microbiology! Congratulations to Erica and Katharina!

September 2015

Two new papers have been published in Advanced Materials Interfaces: "Probing the Role of Mucin-Bound Glycans in Bacterial Repulsion by Mucin Coatings" by Julia Co, Thomas Crouzier, and Katharina Ribbeck, and "Modulating mucin hydration and lubrication by deglycosylation and polyethylene glycol binding" by Thomas Crouzier and Oliver Lieleg. Congratulations to everyone involved!

September 2015

We received an NSF CAREER award for our lab!

May 2015

Congratulations to Dr. Julia Co and Dr. Alona Birjiniuk for their amazing thesis defenses!

March 2015

Welcome to our newest lab member, Jacob Witten!

February 2015

Congratulations to Dr. Kavanaugh for her fabulous thesis defense!!! We are very proud -- she is the first student to graduate from our lab.

January 2015

Congratulations to Katharina Ribbeck for receiving the Junior Bose Award for Excellence in Teaching.

November 2014

-Congrats to Wes for passing his oral quals!!

October 2014

-A new publication has been accepted in Reviews on Progress in Physics: Material properties of biofilms—a review of methods for understanding permeability and mechanics.
Congratulations to Nicole Billings, Alona Birjiniuk, Tahoura Samad and others!

October 2014

-A new publication has been accepted in Applied and Environmental Microbiology: Salivary mucins protect surfaces from colonization by cariogenic bacteria
Congratulations to Erica Shapiro!

October 2014

-A new publication has been accepted in mBio: Mucins Suppress Virulence Traits of Candida albicans.
Congratulations to Nicole Kavanaugh, Angela Zhang and others!

October 2014

-A new publication has been accepted in Scientific Reports: Zebrafish as a Model to Study Live Mucus Physiology
Congratulations to Irena Jetov and others!

September 2014

-Katharina was honored as one of Popular Science's Brilliant 10 of 2014!! Congratulations!!

August 2014

-A new publication has been accepted in Biomacromolecules: Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers. Congratulations to Roberta Polak, Thomas Crouzier and others!

June 2014

-A new publication has been accepted in New Journal of Physics: Single particle tracking reveals spatial and dynamic organization of the E. coli biofilm matrix
Congratulations to Alona Birjiniuk, Nicole Billings and others!

June 2014

-Congratulations to Wes who was awarded a fellowship as part of MIT's Biotechnology Training Program!

June 2014

-Congratulations to Kate who was awarded an NIH/AIDS travel grant!

June 2014

-Congratulations to Tahoura for passing quals!

April 2014

-Congratulations to Tahoura who was awarded a Graduate Research Fellowshipfrom the National Science Foundation!

March 2014

-Welcome to our newest lab members Kowa Chen and Tahoura Samad!

December 2013

-Katharina was featured in this month's MIT News Faculty Highlight. Check it out!

August 2013

- A new publication has been accepted in Biophysical Journal: Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier
Congratulations to Leon Li, Thomas Crouzier, and others!

July 2013

- New publications in Biomacromolecules, PLOS ONE, and PLOS Pathogens are in press! Please see the publications page. Congratulations to Thomas Crouzier, Nicole Billings, and Grace Yao!

January 2013

- Katharina Ribbeck received the 2013 John Kendrew Award for Excellence in Research and Science Communication.

December 2012

- Congratulations to Dr. Leon Li!!

November 2012

- We welcome our newest lab member Wesley Chen, a Biological Engineering graduate student!!

October 2012

- Find us at the 6th ASM Conference on Biofilms in Miami. From September 29th to October 4th.

October 2012

- A new publication has been accepted in Current Biology: Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state
Congratulations to all the authors and in particular to Marina Caldara, Ronn Friedlander and Nicole Kavanaugh!!

September 2012

- Congratulations to Julia who was awarded a Student Traineeship grant from the Cystic Fibrosis Foundation!!

August 2012

- Congratulations to Thomas and Collin for their latest publication in Biomacromolecules entitled Mucin multilayers assembled through sugar-lectin interactions.

July 2012

- A short film on the the wonderful world of mucus, written and directed by Andrew Rajczewski is now available. Go see A Mucus Story.

May 2012

- Congratulations to our own Grace Yao,winner of the BE-BMES Johnson & Johnson Excellence in Biomedical Engineering Research Prize!

January 2012

- Congratulations to Thomas who was awarded the Marie Curie International Outgoing Fellowships for career development (IOF)

Publications

Swimming bacteria promote dispersal of non-motile staphylococcal species | Samad T., Billings N, Birjiniuk A., Crouzier T., Doyle P.S., Ribbeck K.

Accepted in The ISME Journal, 2017

Salivary mucins promote the coexistence of competing oral bacterial species | Frenkel E.S., Ribbeck K.

The ISME Journal, 2017

Antiviral Agents from Multivalent Presentation of Sialyl Oligosaccharides on Brush Polymers | Tang S., Puryear W. B., Seifried B. M., Dong X., Runstadler J. A., Ribbeck K., Olsen B. D.

ACS Macro Letters, 5(3): 2016

Salivary mucins in host defense and disease prevention | Frenkel E.S., Ribbeck K.

Journal of Oral Microbiology, 7: 29759 (2015)

Modulating mucin hydration and lubrication by deglycosylation and polyethylene glycol binding | Crouzier T., Boettcher K., Geonnotti A., Kavanaugh N., Hirsch J.B., Ribbeck K., Lieleg O.

Advanced Materials Interfaces, 2(18): 2015

Probing the Role of Mucin-Bound Glycans in Bacterial Repulsion by Mucin Coatings | Co J., Crouzier T., Ribbeck K.

Advanced Materials Interfaces, 2(17): 2015

Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport | Kim M., Chen W.G., Kang J.W., Glassman M.J., Ribbeck K., Olsen B.D.

Advanced Materials, 27(28): 4207-4212 (2015)

Tuning the properties of mucin via layer-by-layer assembly | Ahn J., Crouzier T., Ribbeck K., Rubner M.F., Cohen R.E.

Biomacromolecules, 16(1): 228-235 (2015)

Material properties of biofilms: a review of methods for understanding permeability and mechanics | Billings N., Birjiniuk A, Samad T., Doyle P., Ribbeck K.

Reports on Progress in Physics: 78(3), 036601 (2015)

Salivary mucins protect surfaces from colonization by cariogenic bacteria | Frenkel E.S., Ribbeck K.

Applied and Environmental Microbiology: 81(1), 332-338 (2014)

Zebrafish as a Model to Study Live Mucus Physiology | Jetov I., Samuelesson T., Yao G., Amsterdam A., Ribbeck K.

Scientific Reports 4, Article Number: 6653 (2014)

Mucins Supress Virulence Traits of Candida albicans | Kavanaugh N.L., Zhang A.Q., Nobile C.J., Johnson, A.D., Ribbeck, K.

mBio, 5(5):e01911-14 (2014)

Sugar-Mediated Disassembly of Mucin/Lectin Multilayers and Their Use as pH-Tolerant, On-Demand Sacrificial Layers | Polak R, Crouzier T, Lim RM, Ribbeck K, Beppu MM, Pitombo RN, Cohen RE, Rubner MF

Biomacromolecules, 15(8):3093-8 (2014)

Single Particle Tracking Reveals Spatial and Dynamic Organization of the E. coli Biofilm Matrix | Birjiniuk, A., Billings, N., Nance, E., Hanes, J., Ribbeck, K., and Doyle, P.S

New Journal of Physics,16() 085014 (2014)

Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier | Li L., Crouzier T., Sarkar A., Dunphy L., Han J., Ribbeck K.

Biophysical Journal, 105(6): 1357-1365 (2013)

Cell patterning with mucin biopolymers | Crouzier T., Jang H., Ahn J., Stocker R., Ribbeck K.

Biomacromolecules,14(9): 3010-3016 (2013)

Cervical Mucus Properties Stratify Risk for Preterm Birth | Critchfield A.S., Yao G., Jaishankar A., Friedlander R.S., Lieleg O., Doyle P.S., McKinley G., House M. and Ribbeck K.

PLOS ONE, 8(8):e69528 (2013)

The extracellular matrix component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms | Billings N., Millan M.R., Caldara M., Rusconi R., Tarasova Y., Stocker R., Ribbeck K.

PLOS Pathogens, 9(8):e1003526 (2013)

Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state | Caldara M., Friedlander R.S., Kavanaugh N., Aizenberg J., Foster K., Ribbeck K.

Current Biology, 22(24): 2325-2330 (2012)

Mucin multilayers assembled through sugar-lectin interactions | Crouzier T, Beckwitt CH, Ribbeck K.

Biomacromolecules, 13(10):3401-8 (2012)

Microfluidic in vitro system for the quantitative study of the stomach mucus barrier | Li, L.D., Lieleg, O., Jang, S.K., Ribbeck, K., Han, J.

Lab Chip, 12(20):4071-9 (2012)

Mucin biopolymers as broad-spectrum antiviral agents | Lieleg, O., Lieleg, C., Bloom, J., Buck, C.B., Ribbeck, K.

Biomacromolecules, 13(6): 1724-1732 (2012)

Selected antimicrobial essential oils eradicate Psuedomonas spp. and Staphylococcus aureus biofilms | Kavanaugh, N.K., Ribbeck, K.

Applied and Environmental Microbiology, 78(11): 4057-4061 (2012)

An absorption chromatography assay to probe bulk particle transport through hydrogels | Vladescu, I., Lieleg, O., Jang, S., and Ribbeck, K.

Journal of Pharmaceutical Sciences, 101(1): 436-42 (2012)

Biological hydrogels as selective diffusion barriers | Lieleg O., Ribbeck K.

Trends in Cell Biology, 21(9), pp. 543-551 (2011)

Mechanical robustness of Pseudomonas aeruginosa biofilms | Lieleg O., Caldara M., Baumgaertal R., Ribbeck K.

Soft Matter, vol.7, Pages 3307-3314 (2011)

Charge as a selection criterion for translocation through nuclear pore complexes | Colwell L., Brenner M., Ribbeck K.

PLoS Computational Biology 6:e1000747 (2010)

Characterization of particle translocation through mucin hydrogels | Lieleg O., Vladescu I., and Ribbeck, K.

Biophysical Journal, 98:1782 (2010)

Do viruses use vectors to penetrate mucus barriers? | Ribbeck K.

Bioscience Hypothesis, Vol. 2, Issue 6, Pages 357-446 (2009)

Adsorption of Human Papillomavirus 16 to live human sperm. | Pérez-Andino J., Buck C.B., and Ribbeck K.

PLoS ONE 4(6):e5847 (2009)

Meiotic Spindle- Sculpted by Severing. | Ribbeck K and Mitchison TJ.

Current Biology 16(21):R923-5 (2007)

Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient. | Clausen T and Ribbeck K.

PLoS ONE 2: e244 (2007)

NuSAP can link mitotic chromatin to microtubules. | Ribbeck K, Raemaekers T, Carmeliet G, Mattaj I.

Current Biology. 17(3):230-6 (2007)

NuSAP, a mitotic RanGTP target that can stabilise and cross-link microtubules. | Ribbeck K, Santarella R, Groen A, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison T, Ellenberg J, Hoenger A and Mattaj I.

Mol Biol Cell 17, 2646-2660 (2006)

Crm1 is a mitotic effector of Ran-GTP in somatic cells. | Arnaoutov A, Azuma Y, Ribbeck K, Joseph J, Boyarchuk Y, Karpova T, McNally J, Dasso M.

Nat Cell Biol. 7(6), 626-32 (2005)

NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. | Raemaekers T, Ribbeck K, Beaudouin J, Annaert W, Van Camp M, Stockmans I, Smets N, Bouillon R, Ellenberg J, Carmeliet G.

J Cell Biol 162, 1017-29 (2003)

Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurement and computer simulation. | Görlich D, Seewald M and Ribbeck K.

EMBO J 22, 1088-110 (2003)

The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. | Ribbeck K and Görlich D.

EMBO J 21, 2664-71 (2002)

Kinetic analysis of translocation through nuclear pore complexes. | Ribbeck K and Görlich D.

EMBO J 20, 1320-1330 (2001)

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. | Bachi A, Braun IC, Rodrigues JP, Pante N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Gorlich D, Carmo-Fonseca M, Izaurralde E.

RNA. 6(1), 136-58 (2000)

The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. | Ribbeck K, Kutay U., Paraskeva E. and Görlich D.

Current Biology 9, 47-50 (1999)

Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. | Bayliss R, Ribbeck K, Akin D, Kent H. M, Feldherr C. M, Görlich D, and Stewart M.

J Mol Biol 293, 579-93 (1999)

A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. | Ferrari MB, Ribbeck K, Hagler DJ, Spitzer NC.

J Cell Biol. 15;141(6):1349-56 (1998).

NTF2 mediates nuclear import of Ran. | Ribbeck K, Lipowsky G., Kent H. M., Stewart M. & Görlich D.

EMBO J 17, 6587-6598 (1998)